Performance of Repeat BinaxNOW Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Testing in a Community Setting, Wisconsin, November 2020–December 2020
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Abstract
Repeating the BinaxNOW antigen test for severe acute respiratory syndrome coronavirus 2 using 2 groups of readers within 30 minutes resulted in high concordance (98.9%) in 2110 encounters. Same-day repeat antigen testing did not significantly improve test sensitivity (77.2% to 81.4%) while specificity remained high (99.6%).
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SciScore for 10.1101/2021.04.05.21254834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are several limitations to this investigation. The population was largely white, non-Hispanic, and older, and the findings may not be generalizable to other settings. Lack of swabbing supervision in other settings could …
SciScore for 10.1101/2021.04.05.21254834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are several limitations to this investigation. The population was largely white, non-Hispanic, and older, and the findings may not be generalizable to other settings. Lack of swabbing supervision in other settings could alter test performance. Among asymptomatic individuals, a larger sample size is needed for more precise sensitivity estimates. RT-PCR was used as the gold standard for SARS-CoV-2 detection; however, since post-infectious individuals recovering from COVID-19 may have prolonged detectable viral shedding, the performance of BinaxNOW assays for detecting contagiousness may vary from these results. This investigation is specific to the BinaxNOW test, and the findings cannot be applied directly to other antigen tests. This investigation provides BinaxNOW test performance in a real-world community setting. The BinaxNOW test exhibits minimal user error and high concordance (98.9%) when repeated at the same encounter offering low yield for capturing additional COVID-19 cases. Symptomatic BinaxNOW positive individuals in moderate-to-high pretest probability situations do not routinely need RT-PCR confirmatory tests because of high test specificity. In certain settings with high prevalence and limited resources, it may also be reasonable to forego RT-PCR confirmation in asymptomatic BinaxNOW positive individuals. Symptomatic negative individuals should continue isolation until RT-PCR confirmation. Quarantine should continue to be emphasized for asymptomatic BinaxNO...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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