Efficient Maternofetal Transplacental Transfer of Anti- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Antibodies After Antenatal SARS-CoV-2 BNT162b2 Messenger RNA Vaccination

  1. Amihai Rottenstreich
  2. Gila Zarbiv
  3. Esther Oiknine-Djian
  4. Roy Zigron
  5. Dana G Wolf
  6. Shay Porat

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Abstract

Maternal and cord blood sera were collected from 20 parturients who received the BNT162b2 vaccine. All women and infants were positive for anti S- and anti-receptor binding domain antibody–specific immunoglobulin G. Cord blood antibody concentrations were correlated to maternal levels and to time since vaccination. Antenatal severe acute respiratory syndrome coronavirus 2 vaccination may provide maternal and neonatal protection.

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  1. Version published to 10.1093/cid/ciab266
  2. ScreenIT

    SciScore for 10.1101/2021.03.11.21253352: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The institutional review board of the Hadassah Medical Center approved this study (HMO-0064-21).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableStudy Population: A prospective study following women admitted for delivery was performed in February 2021 at Hadassah Medical Center, a university affiliated hospital in Jerusalem, Israel.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Spike protein (S) (Liaison SARS-CoV-2 S1/S2 IgG, DiaSorin, Saluggia, Italy) and receptor binding domain (RBD)-specific (Architect SARS-CoV-2 IgG II Quant assay, Abbott Diagnostics, Chicago, USA), IgG levels were evaluated in maternal and cord blood sera.
    Abbott
    suggested: (Abbott, RRID:SCR_010477)
    The data were analyzed using Software Package for Statistics and Simulation (IBM SPSS version 24, IBM Corp, Armonk, NY).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has several caveats, including its small sample size and single-site nature. In addition, the association between gestational age at delivery with transplacental transfer requires further investigation. Moreover, as previously stated, the effect of SARS-CoV-2 vaccination at different times throughout gestation remains to be explored. Our findings demonstrate that antenatal SARS-CoV-2 vaccination induces an adequate maternal serologic response and has the potential to provide neonatal protection through transplacental transfer of vaccine-stimulated maternally-derived antibodies. These encouraging results have important implications for maternal care and the development of appropriate vaccination strategies. Further studies will be needed to better delineate the safety and efficacy of the different maternal SARS-CoV-2 vaccines available and better define transplacental antibody dynamics at earlier gestational ages.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.03.11.21253352 on medRxiv