Frequency of Routine Testing for Coronavirus Disease 2019 (COVID-19) in High-risk Healthcare Environments to Reduce Outbreaks
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Abstract
Routine asymptomatic testing strategies for COVID-19 have been proposed to prevent outbreaks in high-risk healthcare environments. We used simulation modeling to evaluate the optimal frequency of viral testing. We found that routine testing substantially reduces risk of outbreaks, but may need to be as frequent as twice weekly.
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SciScore for 10.1101/2020.04.30.20087015: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The study has limitations in the model assumptions and available data. Transmission of SARS-CoV-2 is documented to have high degree of heterogeneity across settings, whereas we used a transmission rate that considered an average among high-incidence settings such as nursing facilities. Our analysis focused on outbreaks and transmission in high-risk environments, rather than the population at large. Furthermore, routine PCR testing …
SciScore for 10.1101/2020.04.30.20087015: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The study has limitations in the model assumptions and available data. Transmission of SARS-CoV-2 is documented to have high degree of heterogeneity across settings, whereas we used a transmission rate that considered an average among high-incidence settings such as nursing facilities. Our analysis focused on outbreaks and transmission in high-risk environments, rather than the population at large. Furthermore, routine PCR testing would require substantial resources, logistical support, and high participation from the population, with consideration of cost-effectiveness.12 We assumed that results of testing would be available after one day which may only be possible in higher resource settings, but also tested the impact of slower turnaround time, which reduced the overall effectiveness of this strategy. In conclusion, our findings support that routine testing strategies can provide benefit to reduce transmission in high-risk environments with frequent testing but may require complementary strategies to reliably prevent outbreaks of COVID-19. Further evidence should be generated on the use of strategies in combination with testing, including masking, ventilation changes, disinfection, and physical distancing.8,13
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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