High level of protection against COVID-19 after two doses of BNT162b2 vaccine in the working age population – first results from a cohort study in Southern Sweden

  1. Jonas Björk
  2. Malin Inghammar
  3. Mahnaz Moghaddassi
  4. Magnus Rasmussen
  5. Ulf Malmqvist
  6. Fredrik Kahn

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Abstract

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  1. Version published to 10.1080/23744235.2021.1982144
  2. ScreenIT

    SciScore for 10.1101/2021.04.20.21254636: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    14.2 (Stata Corp.) and IBM SPSS Statistics 26
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A limitation was the short follow up time, and the current lack of data to evaluate effects on disease severity and hospitalizations and effects of specific virus variants. Surveillance data compiled by the Public Health Agency of Sweden suggest that 32 – 50% of the positive tests were of the B.1.1.7 variant in the study region during the last follow up period [3]. We also lacked data on disease history and co-existing conditions in the study population, preventing a detailed matching of vaccinated and unvaccinated beyond sex, age and follow up period. The main reason for vaccination in the study cohort was working in the health care sector, but individuals aged up to 64 years who were vaccinated due to their residence in special homes were also included. As we could not account for differences in health related to occupational status and residence across cohorts, we decided not to evaluate effects on all-cause mortality. However, we observed no deaths related to COVID-19 among the vaccinated. As a final limitation, it should be noted that we may to some extent underestimate VE due to unknown prior infections, especially as COVID-19 testing was limited in this population during the spring 2020. Several reports on VE of the BNT162b2 mRNA vaccine have already emerged since the recent launch of large vaccination campaigns in many parts of the world, Although we estimated the VE after 14 days after the first dose, we also studied the effect 0-6 days after the second dose with a c...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.04.20.21254636 on medRxiv