Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients – a prospective observational study
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SciScore for 10.1101/2020.06.29.20140632: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Local Ethics Committee of the HUS Helsinki University Hospital.
Consent: Informed consent was obtained from the patients or the next of kin of those critically ill.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Anemia was defined as hemoglobin < 134 g/l for men and < 117 g/l for women, leukopenia as white blood cells < 3.4 × 109/l and lymphopenia as blood lymphocytes < 1.2 × 109/l and thrombocytopenia as platelet count < 150 × 109/l. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analyses were performed using SPSS version 26.0 (IBM SPSS Statistics®) … SciScore for 10.1101/2020.06.29.20140632: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Local Ethics Committee of the HUS Helsinki University Hospital.
Consent: Informed consent was obtained from the patients or the next of kin of those critically ill.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable Anemia was defined as hemoglobin < 134 g/l for men and < 117 g/l for women, leukopenia as white blood cells < 3.4 × 109/l and lymphopenia as blood lymphocytes < 1.2 × 109/l and thrombocytopenia as platelet count < 150 × 109/l. Table 2: Resources
Software and Algorithms Sentences Resources Statistical analyses were performed using SPSS version 26.0 (IBM SPSS Statistics®) and Stata 16.1 (StataCorp, College Station, TX, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study had several limitations. The sample size was small, which should be taken into account when interpreting the results. All patients admitted to HUS Jorvi Hospital with COVID-19 or influenza were not eligible; for example they lived outside of the Jorvi Hospital catchment area or did not consent to participate. Elderly patients were underrepresented as patients with pre-existing treatment limitations or not requiring specialized care were admitted to the secondary care Espoo Hospital. The time from symptom onset to hospitalization may not be completely comparable between COVID-19 and influenza patients because, until March, only patients with symptom onset within the last 7 days were included. Furthermore, this study is based on clinical data and no extra laboratory testing or radiological imaging was done in addition to the detection of influenza and SARS-CoV-2 RNA. Consequently, CT scans, coagulation markers, cardiac biomarkers or blood gas analyses were mostly not available and thus were not included here. During the COVID-19 epidemic, occasionally SARS-CoV-2 detection alone was conducted without influenza testing on clinical grounds, however, of the COVID-19 patients included in this study, 21 (75%) were tested for influenza and no co-infections were found. In conclusion, COVID-19 requiring hospitalization had a more severe clinical course than influenza. As SARS-CoV-2 and influenza may continue to circulate simultaneously and influenza already strains health care...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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