Added value of anti-SARS-CoV-2 antibody testing in a Flemish nursing home during an acute COVID-19 outbreak in April 2020
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SciScore for 10.1101/2020.05.18.20105874: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The chairman of the ethical review board of the ZOL hospital in Genk confirmed that a formal ethical review was not required. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources To answer the longitudinal questions, we also performed multiple logistic regression, testing the influence of PCR results, participant type (resident or staff), ward, and gender on the presence of sars-CoV-2 antibodies (IgM, IgG, either one of them). IgM, IgGsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are …
SciScore for 10.1101/2020.05.18.20105874: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The chairman of the ethical review board of the ZOL hospital in Genk confirmed that a formal ethical review was not required. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources To answer the longitudinal questions, we also performed multiple logistic regression, testing the influence of PCR results, participant type (resident or staff), ward, and gender on the presence of sars-CoV-2 antibodies (IgM, IgG, either one of them). IgM, IgGsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Strengths and limitations: Testing and reading the results was easy to perform. It was also reassuring that – with one exception – the internal procedural control was positive in all tests, which suggests correct sampling and testing. The one exception was one of the first tests performed, probably due to an insufficient amount of blood. Other validation studies resulted in sensitivities after 14-17 days between 85-100 % (instructions of the producer, Sure Screen Diagnostics, Derby, UK). This is less than perfect, but similar to common Elisa tests. Specificity, which in this situation is the most important, was between 96-99%; which is excellent. Some eligible people were not tested. For staff, this mostly resulted from absence of work without any direct association with COVID-related disease. We therefore do not expect any selection bias resulting from this incompleteness of data. For residents, however, absence resulted mostly from hospitalisation or death. Of course, this can be related to presence of COVID-related disease and some degree of selection bias should be assumed. These numbers are low (mostly less than ten), however, and will not largely influence our results or conclusions. Consequences of our study for clinical work and for future research: Information on antibody status can be useful to support decisions in the further course after a COVID infection. For residents, presence of IgG in association with absence of signs and symptoms and a period of at least two...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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