Disproportionality analysis of adverse neurological and psychiatric reactions with the ChAdOx1 (Oxford-AstraZeneca) and BNT162b2 (Pfizer-BioNTech) COVID-19 vaccines in the United Kingdom
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SciScore for 10.1101/2021.09.28.21264245: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of our study are that it was not possible to control for imbalances in the characteristics of the vaccinated subjects nor to adjust for other factors potentially associated with the reported adverse reactions. A reporter bias might have been …
SciScore for 10.1101/2021.09.28.21264245: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of our study are that it was not possible to control for imbalances in the characteristics of the vaccinated subjects nor to adjust for other factors potentially associated with the reported adverse reactions. A reporter bias might have been present for some reactions.[16] For example, Bell’s palsy reports may have been spurred by the early findings of an imbalance in reported clinical trials with a higher number of cases of facial paralysis seen in subjects receiving Pfizer or Moderna mRNA vaccines as compared to control subjects.[17] Our analysis revealed that ChAdOx1 vaccine was associated with more frequent reports of central nervous system thrombotic events as compared to BNT162b2. These findings coincide with those of Cari and colleagues, who compared the rate of events of thrombocytopenia, bleeding, and blood clots after ChAdOx1 or BNT162b2 in the EudraVigilance European database up to April 16, 2021.[18] Adverse reactions caused by thrombocytopenia, bleeding and blood clots were observed in 33 and 151 reports per 1 million doses of BNT162b2 and ChAdOx1, respectively. Cerebral and splanchnic venous thrombosis were also more frequent with ChAdOx1. The physiopathology of cerebral thrombosis after ChAdOx1 is different from that of thrombotic events unrelated to vaccines and is associated with thrombocytopenia.[19] This syndrome, termed “Vaccine-induced Immune Thrombotic Thrombocytopenia”, has been linked to the presence of circulating autoantibodies against pl...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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