Public health impact of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) in the first year of rollout in the United States

  1. Manuela Di Fusco
  2. Kinga Marczell
  3. Kristen A. Deger
  4. Mary M. Moran
  5. Timothy L. Wiemken
  6. Alejandro Cane
  7. Solène de Boisvilliers
  8. Jingyan Yang
  9. Shailja Vaghela
  10. Julie Roiz

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Abstract

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  1. Version published to 10.1080/13696998.2022.2071427
  2. ScreenIT

    SciScore for 10.1101/2022.02.24.22271478: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    A retrospective analysis of the US Premier Healthcare database (
    Premier Healthcare
    suggested: None
    The cost of managing PASC was also included as a one-off aggregated cost accrued at the time of infection, which included cost elements for number of GP visits, number of COVID-19 tests, the percentage of patients readmitted [67] and/or experiencing PASC.
    PASC
    suggested: (PASC , RRID:SCR_016642)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The results of this study should, however, be considered in the context of several assumptions and limitations. While the vast majority of the model inputs were derived from published COVID-19 literature and national surveillance data, uncertainty existed in parameter estimates and was tested in sensitivity analyses. Other forms of uncertainty (i.e., structural, and methodological) were not explicitly tested. The structures and mechanics used in the model were informed by medical opinion and were consistent with other published models [15-17], the existing data and understanding of the disease. Several simplifications and assumptions were made to minimize unnecessary complexity and deal with data limitations. Due to limited usable data on the spread of SARS-CoV-2 in the community and the effect of vaccination on transmission, our model simplified the epidemiology dynamics and time-dependent effects in a static Markov and decision tree model. Moreover, the model did not directly assess the transmission process and the indirect and herd immunity effects of vaccination, nor the potential therapeutic effects of vaccination in reducing the severity of cases and the impact of PASC, nor the potential macroeconomic savings that could have been achieved over the year through temporal elimination of levels of non-pharmaceutical interventions (NPIs) (e.g., restricted social interactions). Hence, this parsimonious model framework may have generated conservative estimates. These conservat...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.02.24.22271478v1 on medRxiv