A biomarker based severity progression indicator for COVID-19: the Kuwait prognosis indicator score
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SciScore for 10.1101/2020.05.21.20108639: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: Study Design: We obtained ethical approval from the Kuwait Ministry of Health ethical review committee. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our limitations include that the number of patients in our validation cohort was relatively modest. Another consideration is that …
SciScore for 10.1101/2020.05.21.20108639: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: Study Design: We obtained ethical approval from the Kuwait Ministry of Health ethical review committee. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our limitations include that the number of patients in our validation cohort was relatively modest. Another consideration is that our validation was performed in the same country, in Kuwait. Future work will aim to validate our model in other centers, in different countries. We also plan to make our scoring system available online for practicing clinicians to make it more accessible and easier to use.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.05.05.20088906: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: Study Design: We obtained the ethical approval from the Kuwait Ministry of Health ethical review committee. Randomization To test model internal validity, a straightforward and fairly popular approach was used which was to randomly split the data in two parts: one to develop the model and another to measure its performance. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We …SciScore for 10.1101/2020.05.05.20088906: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IACUC: Study Design: We obtained the ethical approval from the Kuwait Ministry of Health ethical review committee. Randomization To test model internal validity, a straightforward and fairly popular approach was used which was to randomly split the data in two parts: one to develop the model and another to measure its performance. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This definition allowed us to capture the spectrum patients who truly required hospital support and treatment to allow prioritization of patients and their treatment at time of diagnosis Although we internally validated our score, a limitation of this study is that it lacks external validation which we will be looking forward to perform with external institutions. Another limitation is the exclusion of patients not achieving the clinical course outcome of the study, including those with recent admission. Strengths include good discrimination and calibration results and use of a machine learning algorithm to improve out-of-sample predictions. In conclusion, this simple prognostic score provides over-burdened health care systems during the pandemic with a much needed tool that can stratify patients at diagnosis. This should facilitate the decision making around admission versus home quarantine and will be of importance to the health care needs of the current pandemic.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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