Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study

  1. Mustafa Zafer Temiz
  2. Ibrahim Hacibey
  3. Ramazan Omer Yazar
  4. Mehmet Salih Sevdi
  5. Suat Hayri Kucuk
  6. Gizem Alkurt
  7. Levent Doganay
  8. Gizem Dinler Doganay
  9. Muhammet Murat Dincer
  10. Emrah Yuruk
  11. Kerem Erkalp
  12. Ahmet Yaser Muslumanoglu

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Abstract

No abstract available

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  1. Version published to 10.1080/0886022x.2022.2032743
  2. ScreenIT

    SciScore for 10.1101/2021.01.10.20249079: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableInclusion criteria were being more than 18 years old males and females, laboratory confirmed COVID-19 patients immediately after their treatment, highly suspected COVID-19 patients with specific computerized tomography (CT) imaging findings [6] before treatment and laboratory confirmed COVID-19 patients under the treatment in intensive care unit (ICU).

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analysis was performed with SPSS Version 22.0 statistic software package (IBM SPSS Inc., Chicago, IL).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The present study has several limitations. First, our cohort has small number of patients. However, we intended to obtain our pilot findings about COVID-19 associated functional impairment in the kidney and kidney damage in default of sufficient data in the literature. Second, even we performed adjusted analysis, other parameters and covariates than our investigated might have played a role on survival analysis. In other respects, our study has some strengths. One of them is, serial monitoring of the serum creatinine levels with available accurate baseline values. Second one is the use of molecular kidney damage markers which could indicate functional alteration in the kidney prior the elevation of serum creatinine levels. This provided us to clearly describe the acute kidney damage by COVID-19 for the first time in the literature. Classification of the COVID-19 patients as before treatment, after treatment and under treatment in ICU might have provided more accurate findings, therefore, it may be accepted as other strength. Finally, this is the first study investigating the predictive role of kidney damage markers in determining the survival outcomes of the patients with COVID-19.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.01.10.20249079v1 on medRxiv