A strategy to optimize the peptide-based inhibitors against different mutants of the spike protein of SARS-CoV-2
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SciScore for 10.1101/2022.02.27.482153: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources The value of γ and β is 0.0378 kcal/mol-Å2 and −0.569 kcal/mol respectively as implemented in the AMBER package. AMBERsuggested: (AMBER, RRID:SCR_016151)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our calculation methodology does have some caveats. First, as we wanted to develop a fast methodology, only the receptor-binding domain of the S-protein and the LCB inhibitor …
SciScore for 10.1101/2022.02.27.482153: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources The value of γ and β is 0.0378 kcal/mol-Å2 and −0.569 kcal/mol respectively as implemented in the AMBER package. AMBERsuggested: (AMBER, RRID:SCR_016151)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our calculation methodology does have some caveats. First, as we wanted to develop a fast methodology, only the receptor-binding domain of the S-protein and the LCB inhibitor were considered. The ACE-2 protein is not considered in the calculation. Our choice of using a simpler system is similar to the work done by williams et al 90.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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