Population Immunity and Covid-19 Severity with Omicron Variant in South Africa
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SciScore for 10.1101/2021.12.20.21268096: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Survey Ethics: The Human Research Ethics Committee at the University of the Witewatersrand granted a waiver for ethics approval of the survey, which was being done at the behest of Guateng Department of Health as part of public health surveillance.
Consent: Neverthless, informed consent was obtained from all indviduals, who were able to decline participation.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources 8 For the calculation of case, hospitalization, and death rates, data were smoothed using a 7-day moving average in STATA version 16.1; weekly rates are … SciScore for 10.1101/2021.12.20.21268096: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Survey Ethics: The Human Research Ethics Committee at the University of the Witewatersrand granted a waiver for ethics approval of the survey, which was being done at the behest of Guateng Department of Health as part of public health surveillance.
Consent: Neverthless, informed consent was obtained from all indviduals, who were able to decline participation.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources 8 For the calculation of case, hospitalization, and death rates, data were smoothed using a 7-day moving average in STATA version 16.1; weekly rates are unsmoothed. STATAsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of our study include the use of publically available data on Covid-19 morbidity and mortality that was collated in surveillance systems and could have changed over time, which could affect comparisons across the four waves. DATCOV surveillance does not distinguish between SARS-CoV-2 cases hospitalized for Covid-19 and those admitted for other illness who coincidentally test positive for SARS-CoV-2 on routine screening. Nevertheless, these systems are unlikely to have changed since the Delta-dominant third wave. Another limitation is that the current wave is only in its fourth week at data cut-off, although the 7-day rolling average of case rate has plateaued and is on a downward trend. Also, our contention that cell-mediated immunity primarily due to natural infection, with or without Covid-19 vaccination, is resulting in the uncoupling of case rates and severe disease remains to be investigated. In particular, the extent to which the polyepitopic T-cell responses induced by vaccination against the spike-protein and the even more diverse polyepitopic T-cell response stimulated by natural infection, with or without vaccination, warrant investigation. As there may be a 1-2 week lag between the surge in SARS-CoV-2 infections and severe Covid-19 cases, monitoring is ongoing to determine whether the uncoupling of case rate and rate of severe illness remains during the current Omicron-dominant wave. If so, we believe it may herald a turning point in the Covid-19 pandemi...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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