Homologous and Heterologous Covid-19 Booster Vaccinations
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SciScore for 10.1101/2021.10.10.21264827: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The trial was reviewed and approved by a central institutional review board and overseen by an independent safety monitoring committee.
Consent: All participants provided written informed consent prior to undergoing any study-related activities.Sex as a biological variable not detected. Randomization 20 For the Beta variant, only a random subset of samples (20 per EUA vaccine, distributed equally between age groups and sites) was analyzed. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
R…SciScore for 10.1101/2021.10.10.21264827: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The trial was reviewed and approved by a central institutional review board and overseen by an independent safety monitoring committee.
Consent: All participants provided written informed consent prior to undergoing any study-related activities.Sex as a biological variable not detected. Randomization 20 For the Beta variant, only a random subset of samples (20 per EUA vaccine, distributed equally between age groups and sites) was analyzed. Blinding not detected. Power Analysis not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has limitations. It was not designed to directly compare responses between different booster regimens. The sample size is insufficient for inter-group comparisons, and the demographics of those studied are not representative of the US population. Volunteers were not randomized into groups, nor stratified with respect to population characteristics or interval from last vaccination. Similarly, the sample size and interim follow-up period were not sufficient to identify rare or late adverse events following booster vaccination, and the interval between completion of the primary series and the booster vaccination evaluated is shorter than the 6 months authorized for BNT162b2. The immunogenicity data are limited to immune responses through Study Day 29, and only serologic responses are reported. The different homologous and heterologous vaccination regimens may vary in terms of cellular and humoral immune responses as well as longevity of the response. In summary, this preliminary report demonstrates that boosting with any of the three vaccines currently licensed or authorized for emergency use in the US will stimulate an anamnestic response in persons who previously received of the primary series of any of these vaccines. Homologous boosts provided a wide range of immunogenicity responses, with heterologous boosts providing comparable or higher titers. Reactogenicity and adverse events were similar across booster groups. These data suggest that if a vaccine is approved ...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04889209 Recruiting Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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