Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

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Abstract

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  1. SciScore for 10.1101/2020.08.27.20183442: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Informed consent was obtained for all enrolled patients.
    IRB: The protocol was reviewed by institutional review boards or ethics committees.
    RandomizationTrial Design and Oversight: COVACTA is a global, multicenter, randomized, double-blind, placebo-controlled, phase 3 trial investigating the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (ClinicalTrials.gov, NCT04320615).
    Blindingnot detected.
    Power AnalysisAn estimated mITT population sample size of 450 patients randomized to tocilizumab or placebo was determined to give 90% power for the primary endpoint using the van Elteren test and an assumed distribution of the …
  2. Imran Khan

    Review 3: "Tocilizumab in Hospitalized Patients With COVID-19 Pneumonia"

    An anti-interleukin-6 antibody, tocilizumab, was found to have no significant differences in mortality or clinical outcomes at day 28, but shorter median time to hospital discharge, compared with placebo in a rigorously conducted randomized control trial.