Effectiveness of mRNA-1273 and BNT162b2 Vaccines in Qatar
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SciScore for 10.1101/2021.11.12.21266250: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards approved this retrospective study with waiver of informed consent, since analysis was done on routinely collected data.
Consent: Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards approved this retrospective study with waiver of informed consent, since analysis was done on routinely collected data.Sex as a biological variable not detected. Randomization Methods for classification of infections by variant type using RT-qPCR variant screening29 of random positive clinical samples23,25 are included in Section 3 in Supplementary Appendix. Blinding not detected. Power Analysis …SciScore for 10.1101/2021.11.12.21266250: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards approved this retrospective study with waiver of informed consent, since analysis was done on routinely collected data.
Consent: Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards approved this retrospective study with waiver of informed consent, since analysis was done on routinely collected data.Sex as a biological variable not detected. Randomization Methods for classification of infections by variant type using RT-qPCR variant screening29 of random positive clinical samples23,25 are included in Section 3 in Supplementary Appendix. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Hazard ratios and corresponding 95% CIs were calculated using Cox regression adjusted for the matching factors with the STATA 17.032 stcox command. STATAsuggested: (Stata, RRID:SCR_012763)Statistical analyses were conducted in STATA/SE version 17.0.32 STROBE checklist is in Table S1. STATA/SEsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has the following limitations. Vaccinated cohorts in Qatar predominantly included young and working-age adults; thus, these findings may not generalize to children or older persons. As an observational study, the vaccinated cohorts were neither blinded nor randomized, so the potential for unmeasured or uncontrolled confounding cannot be excluded. While matching was done for age, sex, nationality, and calendar week of the first (or second) vaccine dose, it was not possible for other factors, such as comorbidities or occupation, as these data were not available to study investigators. However, matching was done to control for major factors known to affect risk of exposure to the infection in Qatar,14,17,26-28 as well as variant exposure over the course of follow-up.6,8,9,19,23-25 Matching by age may have (partially) reduced the potential for bias due to co-morbidities. The number of individuals with severe chronic conditions is also small in Qatar’s young population.14,34 Matching by nationality may have (partially) controlled the differences in occupational risk, in consideration of the association between nationality and occupation in Qatar.14,17,26-28 Both vaccines were broadly distributed across Qatar’s neighborhoods/areas and population social substrata. Individuals were vaccinated by the vaccine that was available at the time of the vaccination appointment. Cohorts were matched by calendar week of the first (or second) dose; thus, vaccination eligibility criter...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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