Effect of Vaccination on Transmission of SARS-CoV-2

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Abstract

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  1. SciScore for 10.1101/2021.03.11.21253275: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Not relevant to studies of previously collected data.
    RandomizationSee Baseline characteristics of vaccinated and unvaccinated healthcare workers and their households by month of first dose in the healthcare workers (Table 1).
    BlindingSARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.
    Power Analysisnot detected.
    Sex as a biological variableMost healthcare workers were women (78·7%) whilst the majority of household members were male.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your data


    Results from LimitationRecognizer: First, the healthcare workers in our analysis were aged between 18 and 65 years of age. We are therefore unable to evaluate the impact on vaccinating elderly or vulnerable individuals. Secondly, differences in individual behaviour concerning testing before and after vaccination could introduce bias. However, this seems an unlikely explanation for our findings since similar results were seen for hospitalisation, consistent results were obtained following the first and second dose, the differences became larger over time which is biologically plausible and the direction of effect were similar in both household members and healthcare workers.

    Results from TrialIdentifier: The statistical analysis was pre-specified prior to linking the outcome and vaccination data (http://www.encepp.eu/encepp/viewResource.htm?id=39737, https://github.com/dmcalli2/hcw_vax).


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • The statistical analysis was pre-specified prior to linking the outcome and vaccination data (http://www.encepp.eu/encepp/viewResource.htm?id=39737, https://github.com/dmcalli2/hcw_vax).

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.