1′-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication
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Abstract
1′-Ribose cyano substitution is essential for Remdesivir to inhibit the nucleotide addition and proofreading in SARS-CoV-2.
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SciScore for 10.1101/2020.04.27.063859: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Experimental Models: Cell Lines Sentences Resources To consolidate the above-mentioned simulation results, we performed in vitro experiments in Vero E6 cells and show that NTP analogues favipiravir, vidarabine and fludarabine indeed fail to inhibit SARS-CoV-2 replication (Fig. 6F). Vero E6suggested: NoneSoftware and Algorithms Sentences Resources All simulations were performed with Gromacs 5.064. Gromacssuggested: (GROMACS, SCR_014565)Results from Barzooka: We also found bar graphs of continuous data. We …
SciScore for 10.1101/2020.04.27.063859: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Experimental Models: Cell Lines Sentences Resources To consolidate the above-mentioned simulation results, we performed in vitro experiments in Vero E6 cells and show that NTP analogues favipiravir, vidarabine and fludarabine indeed fail to inhibit SARS-CoV-2 replication (Fig. 6F). Vero E6suggested: NoneSoftware and Algorithms Sentences Resources All simulations were performed with Gromacs 5.064. Gromacssuggested: (GROMACS, SCR_014565)Results from Barzooka: We also found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).
About SciScore
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