Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus

  1. Baolong Pan
  2. Simon J. Mountford
  3. Maki Kiso
  4. Danielle E. Anderson
  5. Georgina Papadakis
  6. Kate E. Jarman
  7. Danielle R. Tilmanis
  8. Belinda Maher
  9. Thomas Tran
  10. Jake Shortt
  11. Seiya Yamayoshi
  12. Yoshihiro Kawaoka
  13. Philip E. Thompson
  14. Sam A. Greenall
  15. Nadia Warner
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  1. Version published to 10.1038/s43856-025-00863-1
  2. Version published to 10.21203/rs.3.rs-3932156/v1 on Research Square