A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members
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Abstract
Returning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic. In this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of residents living in Centre County prior to the Fall 2020 term at the Pennsylvania State University and following the conclusion of the Fall 2020 term. We also report the seroprevalence in a non-random cohort of students collected at the end of the Fall 2020 term. Of 1313 community participants, 42 (3.2%) were positive for SARS-CoV-2 IgG antibodies at their first visit between 07 August and 02 October 2020. Of 684 student participants who returned to campus for fall instruction, 208 (30.4%) were positive for SARS-CoV-2 antibodies between 26 October and 21 December. 96 (7.3%) community participants returned a positive IgG antibody result by 19 February. Only contact with known SARS-CoV-2-positive individuals and attendance at small gatherings (20–50 individuals) were significant predictors of detecting IgG antibodies among returning students (aOR, 95% CI 3.1, 2.07–4.64; 1.52, 1.03–2.24; respectively). Despite high seroprevalence observed within the student population, seroprevalence in a longitudinal cohort of community residents was low and stable from before student arrival for the Fall 2020 term to after student departure. The study implies that heterogeneity in SARS-CoV-2 transmission can occur in geographically coincident populations.
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SciScore for 10.1101/2021.02.17.21251942: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Antibodies Sentences Resources The presence of anti-SARS-CoV-2 antibodies has been documented in prior seroprevalence studies as a method of quantifying cumulative exposure.21–23 Statistical Methods: Community resident and returning student cohorts’ seroprevalence are presented with binomial 95% confidence intervals. anti-SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources To assist with recruitment into studies under the Data4Action (D4A) Centre County COVID Cohort Study umbrella, a REDCap survey was distributed to residents of Centre County, where respondents could indicate interest in participating in future … SciScore for 10.1101/2021.02.17.21251942: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Antibodies Sentences Resources The presence of anti-SARS-CoV-2 antibodies has been documented in prior seroprevalence studies as a method of quantifying cumulative exposure.21–23 Statistical Methods: Community resident and returning student cohorts’ seroprevalence are presented with binomial 95% confidence intervals. anti-SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources To assist with recruitment into studies under the Data4Action (D4A) Centre County COVID Cohort Study umbrella, a REDCap survey was distributed to residents of Centre County, where respondents could indicate interest in participating in future studies and provide demographic data. REDCapsuggested: (REDCap, RRID:SCR_003445)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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