BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar

  1. Patrick Tang
  2. Mohammad R. Hasan
  3. Hiam Chemaitelly
  4. Hadi M. Yassine
  5. Fatiha M. Benslimane
  6. Hebah A. Al Khatib
  7. Sawsan AlMukdad
  8. Peter Coyle
  9. Houssein H. Ayoub
  10. Zaina Al Kanaani
  11. Einas Al Kuwari
  12. Andrew Jeremijenko
  13. Anvar Hassan Kaleeckal
  14. Ali Nizar Latif
  15. Riyazuddin Mohammad Shaik
  16. Hanan F. Abdul Rahim
  17. Gheyath K. Nasrallah
  18. Mohamed Ghaith Al Kuwari
  19. Hamad Eid Al Romaihi
  20. Adeel A. Butt
  21. Mohamed H. Al-Thani
  22. Abdullatif Al Khal
  23. Roberto Bertollini
  24. Laith J. Abu-Raddad

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Abstract

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  1. Version published to 10.1038/s41591-021-01583-4
  2. ScreenIT

    SciScore for 10.1101/2021.08.11.21261885: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards with waiver of informed consent.
    Consent: The study was approved by the Hamad Medical Corporation and Weill Cornell Medicine-Qatar Institutional Review Boards with waiver of informed consent.
    Sex as a biological variablenot detected.
    RandomizationClassification of infections by variant type: Surveillance for SARS-CoV-2 variants in Qatar is based on viral genome sequencing and multiplex, real-time reverse-transcription PCR (RT-qPCR) variant screening44 of random positive clinical samples2-6, and complemented by deep sequencing of wastewater samples2.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Vaccine effectiveness at different time frames and its associated 95% CI were then calculated by applying the following equation35,36: Statistical analyses were conducted in STATA/SE version 17.045.
    STATA/SE
    suggested: None

    Results from OddPub: Thank you for sharing your data.

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has limitations. Estimated effectiveness against severe, critical, or fatal COVID-19 disease had wider 95% confidence intervals than that against infection, as a consequence of the smaller number of such cases in the young population of Qatar10,34. Data on co-morbid conditions were not available; therefore, they could not be factored explicitly in our analysis. However, adjusting for age may have served as a proxy given that co-morbidities are associated with older age. Furthermore, with the young population of Qatar10,11, we anticipate that only a small proportion of the study population may have had serious co-morbid conditions. Accordingly, our findings may not be generalizable to other settings where the elderly population constitutes a sizable proportion of the population. Effectiveness was assessed using an observational test-negative case-control study design35,36, rather than a randomized clinical trial design where cohorts of vaccinated and unvaccinated individuals were being followed up. However, the cohort study design applied to the same population of Qatar yielded earlier similar findings to the test-negative case-control study design5,6, supporting the validity of this standard approach in assessing vaccine effectiveness for respiratory tract infections35,36. In conclusion, both the BNT162b2 and mRNA-1273 vaccines are highly effective in preventing hospitalization and death due to infection with the Delta variant. However, effectiveness against infect...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.08.11.21261885 on medRxiv