A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
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SciScore for 10.1101/2020.10.13.20212092: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has limitations. First, we used MR to test the effect of circulating protein levels measured in a non-infected state. This is because the effect of the cis-pQTLs upon circulating proteins was estimated in individuals …
SciScore for 10.1101/2020.10.13.20212092: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has limitations. First, we used MR to test the effect of circulating protein levels measured in a non-infected state. This is because the effect of the cis-pQTLs upon circulating proteins was estimated in individuals who had not been exposed to SARS-CoV-2. Once a person contracts SARS-CoV-2 infection, levels of circulating proteins could be altered and this may be especially relevant for cytokines such as IL10 (which binds to IL10RB), whose levels may reflect host response to the viral infection and OAS1, whose levels are increased by activation of interferon pathway, as we observed in our case-control study (Figures S4, S6, S9). Thus, the MR results presented in this paper should be interpreted as an estimation of the effect of circulating protein levels, when measured in the non-infected state. On-going studies will help to clarify if the same cis-pQTLs influence circulating protein levels during infection. Second, this type of study suffers a high false-negative rate. Our goal was not to identify every circulating protein influencing COVID-19 outcomes, but rather to provide evidence for few proteins with strong cis-pQTLs since these proteins are more likely to be robust to the assumptions of MR studies. Future large-scale proteomic studies with more circulating proteins properly assayed should help to overcome these limitations. Third, most MR studies assume a linear relationship between the exposure and the outcome. Thus, our findings would not identify protein...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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