Antibody responses to SARS-CoV-2 in patients with COVID-19

  1. Quan-Xin Long
  2. Bai-Zhong Liu
  3. Hai-Jun Deng
  4. Gui-Cheng Wu
  5. Kun Deng
  6. Yao-Kai Chen
  7. Pu Liao
  8. Jing-Fu Qiu
  9. Yong Lin
  10. Xue-Fei Cai
  11. De-Qiang Wang
  12. Yuan Hu
  13. Ji-Hua Ren
  14. Ni Tang
  15. Yin-Yin Xu
  16. Li-Hua Yu
  17. Zhan Mo
  18. Fang Gong
  19. Xiao-Li Zhang
  20. Wen-Guang Tian
  21. Li Hu
  22. Xian-Xiang Zhang
  23. Jiang-Lin Xiang
  24. Hong-Xin Du
  25. Hua-Wen Liu
  26. Chun-Hui Lang
  27. Xiao-He Luo
  28. Shao-Bo Wu
  29. Xiao-Ping Cui
  30. Zheng Zhou
  31. Man-Man Zhu
  32. Jing Wang
  33. Cheng-Jun Xue
  34. Xiao-Feng Li
  35. Li Wang
  36. Zhi-Jie Li
  37. Kun Wang
  38. Chang-Chun Niu
  39. Qing-Jun Yang
  40. Xiao-Jun Tang
  41. Yong Zhang
  42. Xia-Mao Liu
  43. Jin-Jing Li
  44. De-Chun Zhang
  45. Fan Zhang
  46. Ping Liu
  47. Jun Yuan
  48. Qin Li
  49. Jie-Li Hu
  50. Juan Chen
  51. Ai-Long Huang

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Abstract

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  1. ScreenIT

    SciScore for 10.1101/2020.03.18.20038018: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study was approved by the Ethics Commission of Chongqing Medical University (
    Consent: Written informed consent was waived by the Ethics Commission of the designated hospital for emerging infectious diseases.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    The recombinant antigens containing the nucleoprotein and a peptide from spike protein of SARS-CoV-2 were conjugated with fluorescein isothiocyanate (FITC) and immobilized on the anti-FITC antibody conjugated magnetic particles.
    anti-FITC
    suggested: None
    Alkaline phosphatase conjugated human IgG/IgM antibody was used as the detection antibody.
    human IgG/IgM
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    A limitation of the survey is that only one serum sample for each case was obtained. It is better to confirm the test results by second sampling if possible. In summary, we depict a relatively complete prospect of acute antibody response against SARS-CoV-2 in COVID-19 patients. We believe the antibody test would be of great help in the diagnosis of COVID-19 and the epidemic survey of SARS-CoV-2 infection.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1038/s41591-020-0897-1
  3. Version published to 10.1101/2020.03.18.20038018v1 on medRxiv