The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate
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SciScore for 10.1101/2021.05.27.446014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: SARS-CoV-2 specific antibody testing: ELISAs were conducted as previously described 30,74. Sex as a biological variable Umbilical cord blood was also collected at the time of birth from infants born to healthy mothers at GSTT prior to the COVID-19 pandemic (until 1st Jan 2020), hence their mothers were not infected with SARS-CoV-2 at any time during their pregnancy, termed the Non SARS-CoV-2 Exposed (NSE) group (REC Approval No. 17/LO/0641). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources N-specific monoclonal antibody), CR3022 (0.2 µg/ml) CR3022suggested: NoneSoftware and Algorithms Sentences Resources Flow… SciScore for 10.1101/2021.05.27.446014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Field Sample Permit: SARS-CoV-2 specific antibody testing: ELISAs were conducted as previously described 30,74. Sex as a biological variable Umbilical cord blood was also collected at the time of birth from infants born to healthy mothers at GSTT prior to the COVID-19 pandemic (until 1st Jan 2020), hence their mothers were not infected with SARS-CoV-2 at any time during their pregnancy, termed the Non SARS-CoV-2 Exposed (NSE) group (REC Approval No. 17/LO/0641). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources N-specific monoclonal antibody), CR3022 (0.2 µg/ml) CR3022suggested: NoneSoftware and Algorithms Sentences Resources Flow cytometry data analysis: Raw FCS files were analysed using FlowJo (v10.6.2, BD) and the gating strategies are included in Extended Data Fig. 3. FlowJosuggested: (FlowJo, RRID:SCR_008520)GraphPad Prism (v9.0) was also utilised to generate scatter plots for cytokines and the antibody heatmap. GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 27. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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