A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

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1. Version published to 10.1038/s41565-022-01177-2

   Aug 22, 2022
2. 

   ScreenIT

   Apr 16, 2021

   SciScore for 10.1101/2021.04.13.439641: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: All the human tissue-related work was approved by the ethics committee of the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen (No. 0720) and the ethics committee of Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (SIAT-IRB-200215-H0415). Consent: Written informed consents were obtained from all participating patients.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   Antiviral effect of CIPS on Vero-E6 cells with SARS-CoV-2 post-infection: Vero-E6 cells …

   SciScore for 10.1101/2021.04.13.439641: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Institutional Review Board Statement	IRB: All the human tissue-related work was approved by the ethics committee of the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen (No. 0720) and the ethics committee of Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (SIAT-IRB-200215-H0415). Consent: Written informed consents were obtained from all participating patients.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Sex as a biological variable	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   Antiviral effect of CIPS on Vero-E6 cells with SARS-CoV-2 post-infection: Vero-E6 cells were seeded in 24-well plate overnight with a density of 5×104 cells/well.	Vero-E6 suggested: None
   CIPS effects on SC2-P elimisnation and infection of THP-1 differentiated macrophages: The THP-1 cells were seeded in a 24-well plate with cover slide at a density of 5×104 cell/well (for elimination), or in a 96-well plate at a density of 1×104 cell/well (for infection), and treated with 100 ng/ml PMA 24 h for macrophage differentiation.	THP-1 suggested: None
   Software and Algorithms
   Sentences	Resources
   The occupied space of the cells was analyzed by ImageJ and shown as percentage of the area fraction covered by cells, as an estimate of intact healthy cells in the image.	ImageJ suggested: (ImageJ, RRID:SCR_003070)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Read the original source
3. 

   Version published to 10.1101/2021.04.13.439641 on bioRxiv

   Apr 14, 2021