Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
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Abstract
Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.
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SciScore for 10.1101/2020.04.22.20074336: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Study limitations: The study was based on routinely-collected data and so, as always, data quality issues must be considered. For instance, individuals were considered as having COVID-19 at time of hospitalisation only if they had a test result or diagnosis indicating the disease, which will have led to the omission of individuals who …
SciScore for 10.1101/2020.04.22.20074336: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Study limitations: The study was based on routinely-collected data and so, as always, data quality issues must be considered. For instance, individuals were considered as having COVID-19 at time of hospitalisation only if they had a test result or diagnosis indicating the disease, which will have led to the omission of individuals who can be suspected to have had the disease but lacking confirmation of it. Medical conditions may have been underestimated as they were based on the presence of condition codes, with the absence of such a record taken to indicate the absence of a disease. Meanwhile, medication records indicate that an individual was prescribed or dispensed a particular drug, but this does not necessarily mean that an individual took the drug as originally prescribed or dispensed. Our study could be subject to exposure misclassification with false positives if a patient had a medication dispensing event but did not ingest the drug, but may also be subject to false negatives for non-adherent patients who continued their medication beyond the days of supply due to stockpiling. Medication use estimates based on the data collected at the time of hospitalization is particularly sensitive to misclassification, and may conflate baseline concomitant drug history with immediate treatment upon admission. Comparisons of individuals hospitalised with COVID-19 with individuals previously hospitalised with influenza has limitations. In particular, observed differences may be exp...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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