Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies
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SciScore for 10.1101/2021.01.22.427749: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethical Approval: The study was approved by the Ethics Commission of Chongqing Medical University (reference number 2020003).
Consent: Written informed consent was waived by the Ethics Commission of the designated hospital for emerging infectious diseases.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources The neutralizing antibodies (NAbs) were measured by pseudovirus-based assays in 293T-ACE2 cells. 293T-ACE2suggested: RRID:CVCL_YZ65)Results from OddPub: We did not detect open data. We also …
SciScore for 10.1101/2021.01.22.427749: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethical Approval: The study was approved by the Ethics Commission of Chongqing Medical University (reference number 2020003).
Consent: Written informed consent was waived by the Ethics Commission of the designated hospital for emerging infectious diseases.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources The neutralizing antibodies (NAbs) were measured by pseudovirus-based assays in 293T-ACE2 cells. 293T-ACE2suggested: RRID:CVCL_YZ65)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of this study include its small sample size and the use of non-replicating pseudovirus system. Therefore, further studies with authentic SARS-CoV-2 viruses are required.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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