Disease profile and plasma neutralizing activity of post-vaccination Omicron BA.1 infection in Tianjin, China: a retrospective study

  1. Hong Zheng
  2. Yunlong Cao
  3. Xiaosu Chen
  4. Fengmei Wang
  5. Ye Hu
  6. Weiliang Song
  7. Yangyang Chai
  8. Qingqing Gu
  9. Yansong Shi
  10. Yingmei Feng
  11. Shuxun Liu
  12. Yan Xie
  13. Xiaoliang Sunney Xie
  14. Wentao Jiang
  15. Zhongyang Shen

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Abstract

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  1. Version published to 10.1038/s41422-022-00674-2
  2. ScreenIT

    SciScore for 10.1101/2022.04.09.22273653: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Study Oversight: This study was approved by the Tianjin Municipal Health Commission and the Ethics Committee of Tianjin First Central Hospital (Ethics committee archiving No. 2022N045KY).
    Consent: All patients/participants provided their written informed consent to have their clinical information collected for study purposes and the data generated from the study published.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Cell Line Authenticationnot detected.

    Table 2: Resources

    Experimental Models: Cell Lines
    SentencesResources
    The mixture was added to a monolayer of Vero-E6 cells (5×103 cells per well) in a 96-well plate and incubated for 1 h at 37°C.
    Vero-E6
    suggested: None
    Software and Algorithms
    SentencesResources
    All the analyses were conducted using the SPSS software, version 22.0.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has several limitations. First, the sample of patients is small. Due to effective control efforts, the outbreak was soon contained and the number of cases was thus limited. We covered all cases in our analysis, including asymptomatic patients, to reflect the overall characteristics across all age groups. Second, WGS was performed in the first two cases to confirm that the causative agent was Omicron BA.1, and other cases were regarded as Omicron BA.1 infection based on epidemiological evidence. Tianjin reported the first domestic case of Omicron BA.2 within its municipal area on February 24, 2022, and the other 479 COVID-19 cases reported between February 24 and March 22, 2022 were not included in this study. This study revealed epidemiological and clinical characteristics of the Tianjin outbreak driven by Omicron variant. Child patients tend to present with mild symptoms compared to adults. Full vaccination of the population can reduce the incidence of Omicron infections. Booster dose with inactivated vaccine can provide protection by inducing effective neutralizing antibodies against Omicron variant, reducing the risk of severe disease and ICU admission, and shortening the duration of illness.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2022.04.09.22273653v1 on medRxiv