The basis of a more contagious 501Y.V1 variant of SARS-CoV-2
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SciScore for 10.1101/2021.02.02.428884: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources The bound antibody was detected with AP conjugated goat-anti- human IgG antibody. human IgGsuggested: NoneExperimental Models: Cell Lines Sentences Resources The protein was transiently expressed in 293F cells and purified by nickel column. 293Fsuggested: RRID:CVCL_D615)Software and Algorithms Sentences Resources To docking RBD N501Y mutant to ACE2, the RBD amino acid at position 501 was mutant from Asparagine (N) to Tyrosine (Y) by Coot software(Emsley and … SciScore for 10.1101/2021.02.02.428884: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources The bound antibody was detected with AP conjugated goat-anti- human IgG antibody. human IgGsuggested: NoneExperimental Models: Cell Lines Sentences Resources The protein was transiently expressed in 293F cells and purified by nickel column. 293Fsuggested: RRID:CVCL_D615)Software and Algorithms Sentences Resources To docking RBD N501Y mutant to ACE2, the RBD amino acid at position 501 was mutant from Asparagine (N) to Tyrosine (Y) by Coot software(Emsley and Cowtan 2004b). Cootsuggested: (Coot, RRID:SCR_014222)The structures were shown using PyMOL. PyMOLsuggested: (PyMOL, RRID:SCR_000305)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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