Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

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1. Version published to 10.1038/s41380-022-01632-5

   Jun 14, 2022
2. 

   ScreenIT

   Mar 21, 2022

   SciScore for 10.1101/2022.03.16.22272467: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: Participants: The recruitment of participants was approved by the Institutional Review Board of Universidade Federal de Minas Gerais (UFMG Consent: Written informed consent (digital and printed versions) was provided by all participants in the study.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Initial data collection was conducted using the Research Electronic Data Capture Platform (REDCap) and followed the Brazilian General Data Protection Law (LGPD) [27] for data collection, storage and use.	REDCap suggested: (REDCap, RRID:SCR_003445)
   All valid FDG-PET and …

   SciScore for 10.1101/2022.03.16.22272467: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	IRB: Participants: The recruitment of participants was approved by the Institutional Review Board of Universidade Federal de Minas Gerais (UFMG Consent: Written informed consent (digital and printed versions) was provided by all participants in the study.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Initial data collection was conducted using the Research Electronic Data Capture Platform (REDCap) and followed the Brazilian General Data Protection Law (LGPD) [27] for data collection, storage and use.	REDCap suggested: (REDCap, RRID:SCR_003445)
   All valid FDG-PET and T1-MRI datasets were converted from DICOM format to NIfTI format using DCM2NII software (http://www.cabiatl.com/mricro/mricron/dcm2nii.html), and images were oriented manually to place the anterior commissure at the origin of the three-dimensional Montreal Neurological Institute (MNI) coordinate system.	DCM2NII suggested: (dcm2nii, RRID:SCR_014099)
   Using Statistical Parametric Mapping (SPM), version 12 (Wellcome Trust Center of Neuroimaging, London, United Kingdom), running in MATLAB R2012a (	Statistical Parametric Mapping suggested: (Spatial Statistical Parametric Mapping, RRID:SCR_002592) MATLAB suggested: (MATLAB, RRID:SCR_001622)
   Tests were performed using SPSS 25.0 and GraphPad Prism.	SPSS suggested: (SPSS, RRID:SCR_002865) GraphPad Prism suggested: (GraphPad Prism, RRID:SCR_002798)
   Grouping was performed with the hierarchical clustering algorithm parameterized with Spearman’s correlation and complete linkage, implemented in GenePattern [43].	GenePattern suggested: (GenePattern, RRID:SCR_003201)
   Functional enrichment analysis was performed with the Ingenuity Pathway Analysis (IPA) software (Qiagen).	Ingenuity Pathway Analysis suggested: (Ingenuity Pathway Analysis, RRID:SCR_008653)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   It is mediated by the increase of cytokines and chemokines, reactive oxygen species (ROS) and second lipid messengers produced by astrocytes and microglia, endothelial and peripheral immune cells [78], with self-limitation after resolution [79, 80]. On the other hand, chronic neuroinflammation implies persistent activation of microglia and other immune cells in the CNS with potential damage [81–83]. Amplified or chronic inflammatory activation can lead to pathological changes and neurobehavioral complications, such as depression and cognitive deficits [77, 84, 85]. In this study, we measured peripheral blood immunity associated factors, which might partially correspond to the CNS findings discussed above. Among the 11 upregulated plasma biomarkers in individuals with visuoconstructive deficit, 10 composed a functional network based on experimental observation or high confidence computational predictions that they interact by up-or downregulating each other (Figure 6). These interactions are represented by the broken edges of the network connecting the nodes, which, in turn, represent the protein biomarkers. Furthermore, six of the 10 biomarkers in the network are related to the clinical pathology endpoints hepatic necrosis and five to cardiac necrosis, events that can result in the upregulation of these associated biomarkers. Finally, four biomarkers are components of the canonical “Neuroinflammation Signaling Pathway” and four of the “IL-17 Signaling pathway”. The fact that ...

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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3. 

   Version published to 10.1101/2022.03.16.22272467v1 on medRxiv

   Mar 18, 2022