Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
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SciScore for 10.1101/2021.12.26.472655: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Patients were excluded from this cohort if they had received COVID-19 vaccination by the time of delivery, or if they were deemed unable to provide informed consent and agree to study procedures for any medical or social reason.
IRB: This study was approved by the Boston University Medical Campus Institutional Review Board.Sex as a biological variable This hospital delivers a significant proportion of pregnant patients from minority groups with comorbidities such as hypertension and obesity and having public insurance, which are characteristics associated with severe SARS-CoV-2 disease (18, 19). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
SciScore for 10.1101/2021.12.26.472655: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Patients were excluded from this cohort if they had received COVID-19 vaccination by the time of delivery, or if they were deemed unable to provide informed consent and agree to study procedures for any medical or social reason.
IRB: This study was approved by the Boston University Medical Campus Institutional Review Board.Sex as a biological variable This hospital delivers a significant proportion of pregnant patients from minority groups with comorbidities such as hypertension and obesity and having public insurance, which are characteristics associated with severe SARS-CoV-2 disease (18, 19). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Written informed consent or REDCap e-consent was obtained from all participants. REDCapsuggested: (REDCap, RRID:SCR_003445)All statistical analysis was performed using SAS software V9.4 (SAS Analytics). SASsuggested: (SASqPCR, RRID:SCR_003056)Graphical data for cytokine levels was created using Prism Software (Graphpad) Graphpadsuggested: (GraphPad, RRID:SCR_000306)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The current study has several limitations. First, our cohorts were of moderate sample size and we did not evaluate a complete repertoire of COVID-19 related clinical variables (i.e. c-reactive protein (CRP) levels, white blood cell count). As only a small subset of our cohort had these labs available, they were not included as part of this analysis. Our cohort also had a larger proportion of patients with maternal SARS-CoV-2 infections in early gestation as compared with late gestation. Ongoing analysis with larger cohorts will be required to characterize the cytokine profiles of early vs late pregnancy SARS-CoV-2 infections more completely. As the majority of studies on COVID-19 in pregnancy contain samples exclusively from late pregnancy (3rd trimester) infections, our study highlights the importance of incorporating patients with SARS-CoV-2 infection at multiple gestational stages of pregnancy for ongoing studies in this field. In particular, multivariate analysis to correlate anti-viral antibodies with cytokine profiles will be informative to identify how these inflammatory signatures impact maternal and infant SARS-CoV-2 responses, particularly in relation to gestational timing of maternal infection. This study supports a growing body of evidence that perinatal alterations resulting from maternal COVID-19 in pregnancy have a risk of impacting the health of infants even in the absence of fetal SARS-CoV-2 transmission. Indeed, of all our clinical parameters evaluated betwe...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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