Epicardial adipose tissue thickness is associated with increased COVID-19 severity and mortality
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SciScore for 10.1101/2021.03.14.21253532: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: All proceedings were approved by the research and ethics committee of the INCMNZ (Ref. 3383) and informed consent was waived due to the nature of the study.
Consent: All proceedings were approved by the research and ethics committee of the INCMNZ (Ref. 3383) and informed consent was waived due to the nature of the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This work has certain …
SciScore for 10.1101/2021.03.14.21253532: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: All proceedings were approved by the research and ethics committee of the INCMNZ (Ref. 3383) and informed consent was waived due to the nature of the study.
Consent: All proceedings were approved by the research and ethics committee of the INCMNZ (Ref. 3383) and informed consent was waived due to the nature of the study.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This work has certain strengths and limitations. The study analyses a large number of patients in whom EAT thickness was measured at admission and who were followed throughout hospitalization to record COVID-19 relevant outcomes. Furthermore, this work is novel as it assesses the different types of intrathoracic adipose tissue, including EAT, subthoracic and pericardialm in addition to whole-body adipose tissue measures such as BMI. Using mediation analyses, the degree of contribution of EAT in risk of critical disease and mortality was also quantified. Limitations include the use of EAT thickness instead of volume; this was because the CT scans on admission were simple scans in which volume could not be assessed. There were only a small number of recorded cardiovascular events, this means the full impact of EAT on COVID-19 cardiovascular complications could not be evaluated. The results only apply to moderate or severe infection as mild cases were not included dut to the nature of case recruitment. The study was carried out at a single COVID-19 centre, and the findings may not be representative at a population level. Finally, since abdominal CT scans were not available for most patients, the contribution of thoracic vs. abdominal fat could not be assessed, an area which should be evaluated in future studies. In conclusion, EAT thickness was associated with increased risk for critical COVID-19 and mortality compared to other types of intrathoracic adipose tissue. EAT was also...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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