An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

  1. Jonathan H. Shrimp
  2. Stephen C. Kales
  3. Philip E. Sanderson
  4. Anton Simeonov
  5. Min Shen
  6. Matthew D. Hall

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Abstract

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  1. Version published to 10.1021/acsptsci.0c00106
  2. Version published to 10.1101/2020.06.23.167544v2 on bioRxiv
  3. ScreenIT

    SciScore for 10.1101/2020.06.23.167544: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Experimental Models: Organisms/Strains
    SentencesResources
    Peptides custom ordered from LifeTein (Somerset, NJ) include: Cbz-D-Arg-Gly-Arg-AMC, Cbz-D-Arg-Pro-Arg-AMC.
    Cbz-D-Arg-Gly-Arg-AMC
    suggested: None
    Software and Algorithms
    SentencesResources
    Data normalization, visualization and curve fitting were performed using Prism (GraphPad, San Diego, CA)
    Prism
    suggested: (PRISM, RRID:SCR_005375)
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • No funding statement was detected.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.06.23.167544v1 on bioRxiv