Reproducible Breath Metabolite Changes in Children with SARS-CoV-2 Infection

  1. Amalia Z. Berna
  2. Elikplim H. Akaho
  3. Rebecca M. Harris
  4. Morgan Congdon
  5. Emilie Korn
  6. Samuel Neher
  7. Mirna M’Farrej
  8. Julianne Burns
  9. Audrey R. Odom John

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Abstract

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  1. Version published to 10.1021/acsinfecdis.1c00248
  2. Version published to 10.1101/2020.12.04.20230755v2 on medRxiv
  3. ScreenIT

    SciScore for 10.1101/2020.12.04.20230755: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Study Approval and Enrollment: Prior to enrollment, the study was approved by the CHOP Human Research Ethics Committee (IRB 20-017503) and by the CHOP Institutional Biosafety Committee (IBC 19-000145), for handling of human samples potentially containing SARS-CoV-2.
    IACUC: Study Approval and Enrollment: Prior to enrollment, the study was approved by the CHOP Human Research Ethics Committee (IRB 20-017503) and by the CHOP Institutional Biosafety Committee (IBC 19-000145), for handling of human samples potentially containing SARS-CoV-2.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    (GraphPad Software, San Diego, CA).
    GraphPad
    suggested: (GraphPad Prism, RRID:SCR_002798)
    The data were then processed using RStudio to generate integrated signal for every isolated feature.
    RStudio
    suggested: (RStudio, RRID:SCR_000432)
    The algorithm of the HCPC method, implemented in the FactoMineR package, can be summarized as follow: 1) Compute principal component method; at this step the number of dimensions to be retained in the output is chosen (ncp= 3).
    FactoMineR
    suggested: (FactoMineR, RRID:SCR_014602)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.12.04.20230755v1 on medRxiv