Quantitative Trend Analysis of SARS-CoV-2 RNA in Municipal Wastewater Exemplified with Sewershed-Specific COVID-19 Clinical Case Counts
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SciScore for 10.1101/2022.03.13.22272304: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The goal is to better understand the scope and limitations associated with the QTA process when considering a single sewershed under different normalization modes, parameters and metrics. Note that the detailed analysis of Lv and Lvb normalizations are provided in the Supplement but summarized and discussed here. Figure 3 shows the …
SciScore for 10.1101/2022.03.13.22272304: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The goal is to better understand the scope and limitations associated with the QTA process when considering a single sewershed under different normalization modes, parameters and metrics. Note that the detailed analysis of Lv and Lvb normalizations are provided in the Supplement but summarized and discussed here. Figure 3 shows the Ashbridges Bay WWTP sewershed, overlay plot of the wastewater virus signal (WVS) for PMMoV normalized N1 viral viral concentration (Cvb) (upper right panel) and the cases by reported date (lower right panel) as demonstrated on the Ontario Dashboard. The corresponding aggregated data sets were used to generate trends as part of the QTA under the different normalizing conditions (unnormalized, Cvb, Lv, Lvb), respectively. 3.1.1. PMMoV Normalization (Cvb) and Cases by Reported Date: Figure 4 provides the longer-term QTA of clinical cases by reported date and the PMMoV-normalized wastewater viral concentration from March 21/21 to August 22/21. Table 4 summarizes the trend results with the 95% confidence interval (CI) and Table 5 provides the interpretations based on the PHAC interpretations given in Table 2. The standard errors (SE) associated with the estimated breakpoint and trend slopes for both the CCC and WVS, for each time interval, are provided in Tables 6 and 7, respectively. This is an example of the complete QTA 2-page model report for the WVS metric that may be used directly to inform public health decisions. 3.1.2. PMMoV Normalization (Cvb)...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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