Integrated Metabolomic and Genomic Insights into Amino Acid Incorporation Within the Hybrid Polyketide-Alkaloid Antibiotic TLN-05220

Jennifer L. Cordoza
Rachel A. Johnson
Andrew E. Whiteley
Calista A. Horta
Jayna C. Nicholas
Diana M. Owen
Laura Rodriguez-Velandia
Gordon T. Luu
Valentina Z. Petukhova
Jackson T. Calhoun
Laura M. Sanchez
Shaun M. K. McKinnie
Katharine R. Watts

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Abstract

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Version published to 10.1021/acschembio.5c00877
Jan 30, 2026
Version published to 10.1101/2025.10.30.685158 on bioRxiv
Oct 31, 2025

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