Using Unassigned NMR Chemical Shifts to Model RNA Secondary Structure
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Abstract
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SciScore for 10.1101/2022.01.30.478380: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:In spite of these limitations, the results of our study suggest that with more accurate chemical shift predictors and better techniques for sampling complex secondary structures of RNA, frameworks like the uCS-BME we have implemented will provide an avenue for using unassigned NMR chemical shift data to rapidly generate structural …
SciScore for 10.1101/2022.01.30.478380: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:In spite of these limitations, the results of our study suggest that with more accurate chemical shift predictors and better techniques for sampling complex secondary structures of RNA, frameworks like the uCS-BME we have implemented will provide an avenue for using unassigned NMR chemical shift data to rapidly generate structural hypotheses about the likely underlying secondary structure of large RNAs. One could then use such models as inputs to 3D structure prediction pipelines to arrive at an atomic description of the likely structure of these RNAs. Such atomic structures could then be used to rationalize sequence-structure-function relationships of individual RNAs.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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