Outcomes of SARS-CoV-2 omicron infection in residents of long-term care facilities in England (VIVALDI): a prospective, cohort study
This article has been Reviewed by the following groups
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- Evaluated articles (ScreenIT)
- Evaluated articles (Rapid Reviews Infectious Diseases)
Abstract
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Vincent Auvigne
Review 4: "Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care"
This preprint examines the mortality and hospitalization rates of the SARS-CoV-2 Omnicronvariant and compares them to the Delta variant. Reviewers found the study reliable but requires additional literary citations.
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Srikanth Umakanthan
Review 3: "Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care"
This preprint examines the mortality and hospitalization rates of the SARS-CoV-2 Omnicronvariant and compares them to the Delta variant. Reviewers found the study reliable but requires additional literary citations.
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Jonas Björk
Review 2: "Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care"
This preprint examines the mortality and hospitalization rates of the SARS-CoV-2 Omnicronvariant and compares them to the Delta variant. Reviewers found the study reliable but requires additional literary citations.
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André Peralta-Santos
Review 1: "Outcomes of SARS-CoV-2 Omicron infection in residents of Long-Term Care"
This preprint examines the mortality and hospitalization rates of the SARS-CoV-2 Omnicronvariant and compares them to the Delta variant. Reviewers found the study reliable but requires additional literary citations.
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Strength of evidence
Reviewers: André Peralta-Santos (University of Washington) | 📗📗📗📗◻️
Jonas Björk (Lund University) | 📘📘📘📘📘
Srikanth Umakanthan (The University of the West Indies) | 📗📗📗📗◻️
Vincent Auvigne (Santé Publique France)📒📒📒 ◻️◻️ -
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SciScore for 10.1101/2022.01.21.22269605: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis Formal sample size calculation was not undertaken. Table 2: Resources
Antibodies Sentences Resources Covariates included age (centred at the median), sex, region, LTCF size, prior natural infection (at least one of: previous positive PCR or LFD result in > 28 days before their positive test, prior hospital admission for SARS-CoV-2, or detection of anti-nucleocapsid IgG antibodies). SARS-CoV-2suggested: Noneanti-nucleocapsid IgGsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible …
SciScore for 10.1101/2022.01.21.22269605: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis Formal sample size calculation was not undertaken. Table 2: Resources
Antibodies Sentences Resources Covariates included age (centred at the median), sex, region, LTCF size, prior natural infection (at least one of: previous positive PCR or LFD result in > 28 days before their positive test, prior hospital admission for SARS-CoV-2, or detection of anti-nucleocapsid IgG antibodies). SARS-CoV-2suggested: Noneanti-nucleocapsid IgGsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, our ability to assess the effect of Omicron on mortality is constrained by the duration of follow-up in our study to date. Second, as not all laboratories use assays that include the S-gene target, it was not possible to identify all samples with SGTF or to confirm that samples with SGTF were indeed Omicron. However, all 26 samples that had been sequenced and tested for S-gene were concordant. The recent emergence of a sub-variant of Omicron of the BA.2 lineage that does not exhibit SGTF are unlikely to have affected our results as, based on our analysis of data from the UK’s genomic surveillance programme, only 24 of samples of this lineage have been identified to date. Finally, it is likely that we underestimated the prevalence of past infection in our cohort (10.5%), which is significantly lower than published seroprevalence estimates from the LTCF population, 28 because only a subset of residents had been tested for antibodies to nucleocapsid.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title ISRCTN14447421 NA NA Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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