Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis

  1. Carolyn T Bramante
  2. Nicholas E Ingraham
  3. Thomas A Murray
  4. Schelomo Marmor
  5. Shane Hovertsen
  6. Jessica Gronski
  7. Chace McNeil
  8. Ruoying Feng
  9. Gabriel Guzman
  10. Nermine Abdelwahab
  11. Samantha King
  12. Leonardo Tamariz
  13. Thomas Meehan
  14. Kathryn M Pendleton
  15. Bradley Benson
  16. Deneen Vojta
  17. Christopher J Tignanelli

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  1. ScreenIT

    SciScore for 10.1101/2020.06.19.20135095: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the University of Minnesota institutional review board (STUDY00001489) which provided a waiver of consent for this study.
    Consent: This study was approved by the University of Minnesota institutional review board (STUDY00001489) which provided a waiver of consent for this study.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analyses were performed using Stata MP, version 16 (StataCorp, College Station, TX).
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1016/s2666-7568(20)30033-7
  3. ScreenIT

    SciScore for 10.1101/2020.06.19.20135095: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementThis study was approved by the University of Minnesota institutional review board ( STUDY00001489 ) which provided a waiver of consent for this study .Randomizationnot detected.Blindingnot detected.Power Analysisnot detected.Sex as a biological variableFindings: Metformin was associated with reduced mortality in women who were hospitalized with Covid-19 , but not in men who were hospitalized with Covid-19 .

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analyses were performed using Stata MP , version 16 ( StataCorp , College Station , TX) .
    StataCorp
    suggested: (Stata, SCR_012763)

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

    • Our study has several limitations.
    • First, while claims data shows metformin prescribed as a home medication for at least 90 days within the last 12 months, it does not give information about adherence.

    Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).

    Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.06.19.20135095v2 on medRxiv
  5. Version published to 10.1101/2020.06.19.20135095v1 on medRxiv