Transmission of SARS-CoV-2 by children to contacts in schools and households: a prospective cohort and environmental sampling study in London
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Ashley Murphy
Review 1: "Transmission of SARS-CoV-2 by children attending school. Interim report on an observational, longitudinal sampling study of infected children, contacts, and the environment"
Reviewer: Ashley Murphy (Northwestern University ) | 📒📒📒 ◻️◻️
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Ashley Murphy
Review of "Transmission of SARS-CoV-2 by children attending school. Interim report on an observational, longitudinal sampling study of infected children, contacts, and the environment"
Reviewer: Ashley Murphy (Northwestern University ) | 📒📒📒 ◻️◻️
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SciScore for 10.1101/2021.03.08.21252839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethical approval: The study was approved by a research ethics committee as an amendment to an existing study (Schools Transmission Study REC reference 18/LO/0025; IRAS Reference 225006).
Consent: Informed consent was obtained from all participants or parents/guardians, and assent was obtained from any participant aged under 18.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Samples with high viral load (Ct value <30) were inoculated into Vero cells for culture of infectious virus cell … SciScore for 10.1101/2021.03.08.21252839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethical approval: The study was approved by a research ethics committee as an amendment to an existing study (Schools Transmission Study REC reference 18/LO/0025; IRAS Reference 225006).
Consent: Informed consent was obtained from all participants or parents/guardians, and assent was obtained from any participant aged under 18.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Samples with high viral load (Ct value <30) were inoculated into Vero cells for culture of infectious virus cell culture as previously reported. Verosuggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are limitations to our study. Schools were broadly very supportive, but the burden of supporting a study in the middle of a pandemic was considered too much by some; one school declined to participate despite recruitment of a case and household. Participation of contacts in the bubble group who were quarantined at home was lower than anticipated. A previous longitudinal observational study of scarlet fever transmission achieved 40-50% participation among classroom contacts, although in that study children remained in school apart from index cases (14). In the present study, although a participation rate of almost 30% was achieved in school contacts, participation among bubble contacts who were isolating was only 10-15%, limiting our ability to detect transmission events within the bubble. Exchanging study literature with parents of children who were isolating was challenging, as schools use pared-down communication tools. Participation rates in other COVID-19 research studies have declined markedly since the onset of the pandemic in March, hence research and pandemic fatigue may be another obstacle (15). The participation rate was in contrast to a recently published school study from Norway, where 80% of contacts took part (16). That study, which examined almost 300 school-related contacts of 13 cases, used saliva to screen for secondary cases at the start and end of a 10-day isolation period and reported no secondary cases, albeit 3 cases were identified at the start o...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title ISRCTN13773960 NA NA Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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