Humoral response and PCR positivity in patients with COVID-19 in the New York City region, USA: an observational study
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.04.30.20085613: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was reviewed and approved by our institutional review board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources During the first two weeks of the survey, we tested for SARS-CoV-2 in the nasopharynx by PCR as well as IgG antibody (Ab) in the serum of every individual while in the third week the testing was limited to SARS-CoV-2 antibodies only. SARS-CoV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results …SciScore for 10.1101/2020.04.30.20085613: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was reviewed and approved by our institutional review board. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources During the first two weeks of the survey, we tested for SARS-CoV-2 in the nasopharynx by PCR as well as IgG antibody (Ab) in the serum of every individual while in the third week the testing was limited to SARS-CoV-2 antibodies only. SARS-CoV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are limitations to our evaluation. All participants had mild disease, and thus these data may not reflect PCR or Ab findings in a moderately or severely ill population. Participants were recruited based on self-referral and self-reporting, which may have led to recall bias in terms of dates of symptom onset, resolution and duration, and may have led us to miss asymptomatic carriers who did not inquire about testing. Additionally, given recruitment via an English-language online survey and our use of a single collection site, our sample likely included more recovered participants of younger ages with internet access and the ability to travel to our site for testing. Furthermore, we did not collect rigorous data regarding symptom severity which could potentially be related to the timeline and strength of IgG antibody response to SARS-CoV-2. Future studies are planned to help us understand the magnitude and duration of the IgG response in patients recovered from SARS-CoV-2, and what antibody titer may be necessary to protected individuals from reinfection. We also hope to better understand which, if any, patients do not mount an IgG immune response. Finally, the clinical significance of prolonged positive SARS-CoV-2 nasopharyngeal PCR in the absence of symptoms requires further clarification.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
