Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
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SciScore for 10.1101/2021.04.13.21255411: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization All randomized trials, comparative studies and observational studies, published as full text in English were included, while editorials, conference abstracts, animal studies, case reports, articles not written in English language or not providing full text were excluded. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Search was conducted on December 28, 2020 and repeated on January 22, 2021 by two independent authors (E.K. and E.J.G.B) across MEDLINE (PubMed), Cochrane, medRxiv.org, biorxiv.org and clinicaltrials.gov databases using the following terms: “COVID-19” … SciScore for 10.1101/2021.04.13.21255411: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization All randomized trials, comparative studies and observational studies, published as full text in English were included, while editorials, conference abstracts, animal studies, case reports, articles not written in English language or not providing full text were excluded. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Search was conducted on December 28, 2020 and repeated on January 22, 2021 by two independent authors (E.K. and E.J.G.B) across MEDLINE (PubMed), Cochrane, medRxiv.org, biorxiv.org and clinicaltrials.gov databases using the following terms: “COVID-19” or “SARS-CoV-2” and “anakinra”, “interleukin-1”, “interleukin blockade”. MEDLINEsuggested: (MEDLINE, RRID:SCR_002185)All statistical analyses were done using SPSS (version 23) and Review Manager (version 5.3). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Although the design clearly has its limitations, as general care for COVID-19 patients improved over time, possibly regardless of the anakinra treatment, the observed magnitude of protective effect of anakinra was convincing enough to continue with additional studies that globally supported a positive effect of anakinra in severe forms of COVID-19. The open-label single-arm phase II prospective SAVE trial concluded not only that suPAR-guided anakinra treatment prevented onset of respiratory failure necessitating mechanical ventilation but also reduced both short (30-day)- and long (90-day)-mortality compared with standard-of-care alone (28). suPAR is an early predictor of some of the most critical COVID-19 outcomes, including respiratory failure, kidney failure and mortality (31,32). The only randomized controlled trial published so far was initiated by the French consortium CORIMUNO, but was prematurely interrupted following enrolment of 59 anakinra and 55 usual care patients because of assumed futility (23). The results from the CORIMUNO-ANA-1 study suggest that anakinra was not effective in reducing the need for non-invasive or mechanical ventilation or death in patients with COVID-19 and mild-to-moderate pneumonia. However, in the CORIMUNO-ANA-1 study, the day-14 mortality was 15% in the anakinra group compared to 24% in the usual care group and the WHO Clinical Progression Scale (CPS) was also suggestive for a beneficial effect of anakinra at day 14. Unfortunately, stopp...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04680949 Active, not recruiting suPAR-Guided Anakinra Treatment for Management of Severe Res… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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