Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study
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SciScore for 10.1101/2022.01.20.22269599: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The Ethics Committee of the German-Saxonian Board of Physicians, Dresden, Germany (number, EK-BR-88/20.1) and the Institutional Review Boards of the recruiting sites provided ethical clearance.
Consent: 4 Eligible patients were non-anuric adults (≥18 years), capable to give written informed consent, with PCR-confirmed SARS-CoV-2 infection diagnosed in ambulatory care or on the first hospitalisation day.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources For database management and statistical analysis, SAS software version 9·4 was used. SASsuggested: (SASqPCR, RRID:SC…SciScore for 10.1101/2022.01.20.22269599: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: The Ethics Committee of the German-Saxonian Board of Physicians, Dresden, Germany (number, EK-BR-88/20.1) and the Institutional Review Boards of the recruiting sites provided ethical clearance.
Consent: 4 Eligible patients were non-anuric adults (≥18 years), capable to give written informed consent, with PCR-confirmed SARS-CoV-2 infection diagnosed in ambulatory care or on the first hospitalisation day.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources For database management and statistical analysis, SAS software version 9·4 was used. SASsuggested: (SASqPCR, RRID:SCR_003056)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Nevertheless, the current results must be interpreted within the context of obvious limitations. First, CRIT-CoV-U is an observational cohort study. Randomised clinical trials should consolidate the optimal strategy for applying treatments guided by COV50 risk profiling. Second, as outlined above, future research should address the health-economic implications of the timing and choice of therapeutic interventions in patients with a low vs high risk COV50 score. Third, CRIT-Cov-U enrolled adults and predominantly white Europeans. How ethnicity might affect the UPP is currently under investigation in the Urinary Proteomics Combined with Home Blood Pressure Telemonitoring for Health Care Reform trial (NCT04299529).31 Finally, although UPP risk profiling provides insights on the ideal timing of intervention, vaccination remains by far the primordial strategy in addressing the COVID-19 pandemic, although vaccination alone connot be sufficient to restore the pre-COVID-19 way of living.32 In conclusion, COV50 is the first biomarker predictive of death and disease progression in adult COVID-19 patients. Independent of clinical risk markers, the operational COV50 thresholds have a discriminatory accuracy or around 70%, even in patients with mild disease. A high-risk COV50 test administered within 4 days of a positive PCR-test justifies earlier treatment in patients with mild-to-moderate disease (WHO scores 1-5), in whom clinical risk factors often leave the prognosis uncertain. Anothe...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04299529 Not yet recruiting Urinary Proteomics Combined With Home Blood Pressure Telemon… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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