Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
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SciScore for 10.1101/2021.12.13.21267471: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Written informed consent was obtained from all study participants.
IRB: The study was approved by the Leeds West Research Ethics Committee (20/YH/0225) and is registered on the ISRCTN Registry (ISRCTN10980107).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources We used R (version 3·6·3) with the finalfit, tidyverse, mice, cluster, ggplot2, ggalluvial, radiant, dabestr and recipes packages. ggplot2suggested: (ggplot2, RRID:SCR_014601)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data …
SciScore for 10.1101/2021.12.13.21267471: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Written informed consent was obtained from all study participants.
IRB: The study was approved by the Leeds West Research Ethics Committee (20/YH/0225) and is registered on the ISRCTN Registry (ISRCTN10980107).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources We used R (version 3·6·3) with the finalfit, tidyverse, mice, cluster, ggplot2, ggalluvial, radiant, dabestr and recipes packages. ggplot2suggested: (ggplot2, RRID:SCR_014601)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:However, there are limitations. There will be selection bias for participants returning for a one-year visit, although we have not found overt differences between the demographics, or five-month recovery status between attendees and non-attendees of the one-year visit. Notwithstanding this limitation, even with the assumption of all participants with missing data having fully recovered then the highest estimate is 60% of participants feeling fully recovered at one year demonstrating a substantial proportion with ongoing new morbidity. Our cohort has a higher proportion of patients requiring IMV than typically seen in UK hospitals38 and therefore our results may not be directly generalisable to the wider population. To reduce uncertainty of the impact of pre-existing illness, we asked our recruits whether they felt fully recovered i.e., back to their normal. We also asked them retrospectively to estimate their pre-COVID-19 health status including the most prevalent symptoms, disability and health-related quality of life; we recognise there might be recall bias. Data linkage to electronic patient records is in process, but not currently available so in the current report pre-existing co-morbidities were self-reported and data regarding hospital admissions and mortality in the first year are unavailable. Our study suggests that persistent inflammation may be underlying ongoing impairment in some participants; the specific mechanisms underlying this signal require further investi...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title ISRCTN10980107 NA NA Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
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