CoronaVac induces lower neutralising activity against variants of concern than natural infection
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SciScore for 10.1101/2021.07.10.21260232: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Detection antibody was removed by washing the plate 3 more times, then 1:2000 HRP-conjugated goat anti-rabbit polyclonal antibody (Dako, Denmark A/S, Cat#P0448) was added and the plate incubated at 37°C for 1h. anti-rabbitsuggested: (Agilent Cat# P0448, RRID:AB_2617138)Experimental Models: Cell Lines Sentences Resources African green monkey (Cercopithecus aethiops) kidney epithelial cells (Vero cells) (ATCC CCL-81) were used for virus isolation and a Vero cell derivative (Vero E6 cells) … SciScore for 10.1101/2021.07.10.21260232: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Detection antibody was removed by washing the plate 3 more times, then 1:2000 HRP-conjugated goat anti-rabbit polyclonal antibody (Dako, Denmark A/S, Cat#P0448) was added and the plate incubated at 37°C for 1h. anti-rabbitsuggested: (Agilent Cat# P0448, RRID:AB_2617138)Experimental Models: Cell Lines Sentences Resources African green monkey (Cercopithecus aethiops) kidney epithelial cells (Vero cells) (ATCC CCL-81) were used for virus isolation and a Vero cell derivative (Vero E6 cells) (ATCC CRL-1586) was used for virus propagation. Verosuggested: ATCC Cat# CRL-1586, RRID:CVCL_0574)The B.1.1.7 (SARS-CoV-2/human/THA/NH657_P3/2021) and B.1.617.2 (SARS-CoV-2/human/THA/OTV007_P3/2021) variants were isolated from nasopharyngeal swab samples from RT-PCR confirmed COVID-19 patients provided by Ramathibodi Chakri Naruebodindra Hospital (Chakri Naruebodindra Medical Institute), Samut Prakan, Thailand. The B.1.351 variant (SARS-CoV-2/human/THA/NH088_P3/2021) was isolated from a nasopharyngeal swab sample from an RT-PCR confirmed COVID-19 patient provided by the Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. For B.1.1.7, B.1.617.2 and B.1.351, Vero E6 cells were used for both virus isolation and propagation. Vero E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources The BLASTn results were then used to construct alignments of the reads. BLASTnsuggested: (BLASTN, RRID:SCR_001598)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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