CovMT: an interactive SARS-CoV-2 mutation tracker, with a focus on critical variants

  1. Intikhab Alam
  2. Aleksandar Radovanovic
  3. Roberto Incitti
  4. Allan A Kamau
  5. Mohammed Alarawi
  6. Esam I Azhar
  7. Takashi Gojobori

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Abstract

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  1. Version published to 10.1016/s1473-3099(21)00078-5
  2. ScreenIT

    SciScore for 10.1101/2021.01.22.21249716: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Experimental Models: Organisms/Strains
    SentencesResources
    For each gene, an MF signature shows the name of the gene or INTGEN for intergenic mutations, followed by the count of mutations and coordinates at the protein level as well as genome level, as shown below for the MF related to above shown MF ID: E:1(P71L;C26456T)|INTGEN:2(INTGEN;G174T|INTGEN;C241T)|M:1(N41;C26645T)|N:1(T205I ;C28887T)|ORF3a:2(Q57H;G25563T|S171L;C25904T)|ORF8:1(F120;C28253T)|S:5(L18F;C216 14T|D80A;A21801C|D215G;A22206G|D614G;A23403G|A701V;C23664T)|S_RBD:3(K417N;G2 2813T|E484K;G23012A|N501Y;A23063T)|orf1ab:6(T265I;C1059T|T809;A2692T|F924;C3037T| K1655N;G5230T|K3353R;A10323G|P4715L;C14408T) If we remove the coordinates of the mutations, a MF would show the count of mutations per gene, as shown below: E:1|INTGEN:2|M:1|N:1|ORF3a:2|ORF8:1|S:5|S_RBD:3|orf1ab:6 All MFs are available for exploration at CovMT webpage: https://www.cbrc.kaust.edu.sa/covmt/index.php?p=world-variants All MFs are available for exploration at CovMT mutant variant table (1).
    K417N;G2 2813T|E484K;G23012A|N501Y;A23063T)|orf1ab:6
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.01.22.21249716v1 on medRxiv