Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis

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Abstract

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  1. SciScore for 10.1101/2020.03.18.20038125: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementConsent: Informed consent, both written and oral, was obtained from all enrolled patients.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    The major limitations of the present study were selection bias and low number of patients. We enrolled an ideal, homogeneous cluster of relatively healthy individuals who could remain on board a cruise ship for a relatively long term. Therefore, the patient population was not an exact representation of normal clinical settings. Triage on the Diamond Princess cruise ship before emergency transportation has also introduced a selection bias with an atypically large number of patients. The Self-Defense Forces Central Hospital in Tokyo is close to the Yokohama port where the cruise ship was docked, and the symptomatic cases were referred to the study hospital. However, the critical cases were preferentially referred to neighboring hospitals in Yokohama. Likewise, several clinical signs and symptoms, which have occurred and disappeared before the patients were referred to our hospital, may be included or excluded from this study. In addition, laboratory tests and CT images were obtained once in majority of the patients, and the present study was not able to determine changes in lymphocyte count and radiological findings over the course of observation. Therefore, multicenter, multi-national cohort studies should be conducted to determine predictive markers for symptom onset and risk factors for diseases progression.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.