ROLE OF ANTIBODIES, INFLAMMATORY MARKERS, AND ECHOCARDIOGRAPHIC FINDINGS IN POST-ACUTE CARDIOPULMONARY SYMPTOMS AFTER SARS-COV-2 INFECTION
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SciScore for 10.1101/2021.11.24.21266834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Study Approval: All participants provided signed written informed consent prior to participation.
IRB: Institutional Review Board approval was granted by the University of California, San Francisco. Dr.Sex as a biological variable not detected. Randomization not detected. Blinding A blinded cardiac sonographer performed echocardiograms using a standardized protocol with a GE VIVID E90 machine. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Echocardiograms were measured and post-processed by a single echocardiographer with GE EchoPAC software. GE EchoPACsuggested: NoneData were recorded using REDCap. REDCapsuggested: (REDCap, RRID:SCR_003445)Statistical… SciScore for 10.1101/2021.11.24.21266834: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Study Approval: All participants provided signed written informed consent prior to participation.
IRB: Institutional Review Board approval was granted by the University of California, San Francisco. Dr.Sex as a biological variable not detected. Randomization not detected. Blinding A blinded cardiac sonographer performed echocardiograms using a standardized protocol with a GE VIVID E90 machine. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Echocardiograms were measured and post-processed by a single echocardiographer with GE EchoPAC software. GE EchoPACsuggested: NoneData were recorded using REDCap. REDCapsuggested: (REDCap, RRID:SCR_003445)Statistical analyses were performed using StataMP 16.1 (StataCorp, College Station, TX). StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Study Limitations: Limitations of this study include the use of a convenience sample and the cross-sectional echocardiographic and biomarker assessments. There is a risk of selection bias from those in the LIINC study who chose to participate in the cardiovascular sub-study, and from the shift in our recruitment criteria toward those with symptoms. To date, there are no formal definitions of cardiopulmonary PASC. We did not have echocardiograms from prior to or during acute infection to examine sub-clinical changes among our sample. Because we are specifically interested in the pathophysiology of persistent symptoms compared to those who fully recover from COVID-19, we intentionally did not include a SARS-CoV-2 uninfected control group, but inclusion of such a control group would have strengthened our inferences. We excluded those with pre-existing heart failure, congenital heart disease, and pulmonary hypertension, so our findings may not be generalizable to those with pre-existing cardiac disease. Third, because we only included a small number of people who received intensive care during acute COVID-19 and none with myocarditis in the setting of acute disease, our findings may not be applicable to those with the highest severity of illness. Finally, the number with pericardial effusions is small so findings particularly with respect to biomarkers and pericardial effusions should be confirmed in larger studies.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04362150 Recruiting Long-term Impact of Infection With Novel Coronavirus (COVID-… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 33. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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