Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study
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SciScore for 10.1101/2022.05.26.22275631: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the institutional review board of the University of Hong Kong / Hospital Authority Hong Kong West Cluster (reference no. UW 20-493).
Consent: Given the extraordinary nature of the COVID-19 pandemic, individual patient-informed consent was not required for this retrospective cohort study using anonymized data.Sex as a biological variable not detected. Randomization Up to ten control patients were randomly matched with each of the case according to age (within the same year), sex, date of COVID diagnosis (within the same date), Charlson Comorbidity Index (CCI), and full SARS-CoV-2 vaccination (with at least two doses of Comirnaty or three doses of CoronaVac). Blindi… SciScore for 10.1101/2022.05.26.22275631: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: This study was approved by the institutional review board of the University of Hong Kong / Hospital Authority Hong Kong West Cluster (reference no. UW 20-493).
Consent: Given the extraordinary nature of the COVID-19 pandemic, individual patient-informed consent was not required for this retrospective cohort study using anonymized data.Sex as a biological variable not detected. Randomization Up to ten control patients were randomly matched with each of the case according to age (within the same year), sex, date of COVID diagnosis (within the same date), Charlson Comorbidity Index (CCI), and full SARS-CoV-2 vaccination (with at least two doses of Comirnaty or three doses of CoronaVac). Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources All statistical analyses were performed using Stata version 17 (StataCorp LP, College Station, TX). StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Nevertheless, a number of study limitations should be acknowledged. Firstly, residents at the RCHE were excluded from the current analysis because of substantial missing records, complex referral patterns between different levels and categories of treatment facilities and/or prolonged delays in oral antiviral prescription during the peak of this pandemic wave. Further studies are needed to examine the real-world safety and effectiveness of oral antivirals in specific healthcare settings, for instance, nursing homes and residential care facilities. Secondly, indication bias could not be eliminated in the prescription of oral antivirals, as reflected by the considerably older age and lower percentage of patients who had been fully vaccinated among oral antiviral users than matched controls at baseline. Indication bias might also be present in the clinical decision to prescribe molnupiravir versus nirmatrelvir/ritonavir, as the latter could be confounded by its significant drug-drug interactions. After matching, patient characteristics between oral antiviral and respective control groups were well balanced at baseline. Thirdly, some information biases might exist in the collection of data during the peak of this pandemic wave, such as the self-reporting of COVID-19 cases based on positive RAT with varying sensitivity. Lastly, there might have been an underreporting of COVID-19 cases during the study period, and the overwhelmed public healthcare system might have prevented some p...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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