The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2020.12.26.424423: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources It is expected that VERO E6 cells in the presence of the SARS-CoV2 virus will demonstrate a decrease in CI values. VERO E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources Montelukast structure was downloaded from PubChem (https://pubchem.ncbi.nlm.nih.gov/) and LigPrep module of the Maestro molecular modeling package was used in ligand preparation with OPLS3e force field. PubChemsuggested: (PubChem, RRID:SCR_004284)https…SciScore for 10.1101/2020.12.26.424423: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources It is expected that VERO E6 cells in the presence of the SARS-CoV2 virus will demonstrate a decrease in CI values. VERO E6suggested: RRID:CVCL_XD71)Software and Algorithms Sentences Resources Montelukast structure was downloaded from PubChem (https://pubchem.ncbi.nlm.nih.gov/) and LigPrep module of the Maestro molecular modeling package was used in ligand preparation with OPLS3e force field. PubChemsuggested: (PubChem, RRID:SCR_004284)https://pubchem.ncbi.nlm.nih.gov/suggested: (PubChem BioAssay, RRID:SCR_010734)Protein preparation tool of Maestro was used in both targets at physiological pH. Maestrosuggested: (Maestro, RRID:SCR_016748)The results were plotted with GraphPad Prism 8.0 software (GraphPad, San Diego CA, USA). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-