Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir

  1. Qi Peng
  2. Ruchao Peng
  3. Bin Yuan
  4. Min Wang
  5. Jingru Zhao
  6. Lifeng Fu
  7. Jianxun Qi
  8. Yi Shi

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Abstract

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  1. Version published to 10.1016/j.xinn.2021.100080
  2. ScreenIT

    SciScore for 10.1101/2020.10.19.345470: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The RNA products were quantified by integrating the intensity of each band using ImageJ software.
    ImageJ
    suggested: (ImageJ, RRID:SCR_003070)
    Cryo-EM data was automatically collected using SerialEM software (http://bio3d.colorado.edu/SerialEM/).
    SerialEM
    suggested: (SerialEM, RRID:SCR_017293)
    Image processing: The movie frames were aligned using MotionCor2 to correct beam-induced motion and anisotropic magnification38.
    MotionCor2
    suggested: (MotionCor2, RRID:SCR_016499)
    The structure of FTP was built using the “Ligand builder” plug-in in COOT and manually fitted into the density.
    COOT
    suggested: (Coot, RRID:SCR_014222)
    The figure was generated with PyMOL.
    PyMOL
    suggested: (PyMOL, RRID:SCR_000305)

    Results from OddPub: Thank you for sharing your data.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).

    Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on pages 15, 16, 28, 29 and 30. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.10.19.345470v1 on bioRxiv